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UN-1, a murine monoclonal antibody recognizing a human thymocyte undescribed antigen

Authors
Publisher
Elsevier Ltd
Publication Date
Volume
26
Identifiers
DOI: 10.1016/1043-6618(92)90630-t
Keywords
  • Monoclonal Antibody
  • Human Thymocytes

Abstract

Abstract A monoclonal antibody (MoAb), UN-1, specific for a human thymocyte cell surface antigen was produced. The same MoAb recognized in immunofluorescence also cells of the human T line HPB-ALL, while did not bind human peripheral blood cells and cells of some T, B and myeloid lines. Western blotting analysis of thymocyte membranes with MoAb UN-1 revealed a structure with a molecular weight of 150 kDa. Therefore both the pattern of expression and the size of the antigen recognized by MoAb UN-1 did not correspond to any previously described cell surface molecule.

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