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A rush to judgment on Th17

Authors
Journal
Journal of Experimental Medicine
0022-1007
Publisher
The Rockefeller University Press
Publication Date
Volume
205
Issue
7
Identifiers
DOI: 10.1084/jem.20072066
Keywords
  • Commentaries
  • Commentary
Disciplines
  • Biology
  • Medicine

Abstract

Some immunologists have characterized T helper (Th)17 T cells as the master mediators of tissue damage in a variety of pathological conditions. New data now demonstrate that Th1 and Th17 T cells are independently capable of inducing disease in two established models of autoimmunity. Thus, the role of Th17 cytokines as the central mediators of pathological tissue damage seems to require clarification.

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