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Antileishmanial activities of macrophages from C3H/HeN and C3H/HeJ mice treated withMycobacterium bovisstrain BCG

Authors
Journal
Cellular Immunology
0008-8749
Publisher
Elsevier
Publication Date
Volume
80
Issue
2
Identifiers
DOI: 10.1016/0008-8749(83)90110-7

Abstract

Abstract C3H/HeN and C3H/HeJ mice were infected ip with viable BCG, a macrophage-activating agent, and their peritoneal exudate macrophages exposed to Leishmania tropica amastigotes. Macrophages from BCG-infected C3H/HeJ mice had both leishmanicidal activities described for lymphokine activation of C3H/HeJ macrophages in vitro: increased resistance to L. tropica infection, followed by intracellular killing of the parasite. Macrophages from BCG-infected C3H/HeJ mice were also activated to kill tumor cells in vitro. In contrast, macrophages from BCG-treated C3H/HeJ mice were not resistant to L. tropica infection, did not kill intracellular amastigotes over 72 hr in culture, and were not cytotoxic to tumor cells.

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