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Effect of electrical stimulation of the reticular nucleus of the rat thalamus uponc-fosimmunoreactivity in the retrosplenial cortex

Authors
Journal
Annals of Anatomy - Anatomischer Anzeiger
0940-9602
Publisher
Elsevier
Publication Date
Volume
187
Issue
3
Identifiers
DOI: 10.1016/j.aanat.2004.11.004
Keywords
  • Thalamus
  • Reticular Nucleus
  • C-Fos
  • Electrical Stimulation
  • Immunohistochemistry
  • Attentional Gating
Disciplines
  • Chemistry

Abstract

Summary Electrical stimulation of the reticular nucleus of the rat thalamus results in activation of c-fos immunoreactivity in nerve cells of the ipsilateral retrosplenial cortex. The c-fos immunoreactive neurons are mainly concentrated in lamina IV of the retrosplenial cortex. Conversely, electrical stimulation of the retrosplenial cortex induced c-fos immunoreactivity in the ipsilateral reticular nucleus of the thalamus. The results of the electrical stimulation suggest a direct synaptic connection between the cerebral cortex and the ipsilateral reticular thalamic nucleus. Simultaneous immunohistochemical staining proves that the majority of nerve cells and dendro-dendritic terminals in the reticular thalamic nucleus contain parvalbumine and, at the same time, also GABA. The role of GABA-ergic parvalbumine immunoreactive terminals in the reticular thalamic nucleus seems to be related to integration and processing of impulses and attentional gating, distinguishing between noxious and innocuous inputs.

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