Breast cancer is the most frequently researched cancer in the sense of influence of psychosocial factors on course and development of cancer, i.e. influence of all factors on quality of life of diseased. There are many reasons for this interest: it is the most common cancer appearing in women, it spreads over an organ which is intimately associated with psychological factors which are of great importance for every woman, and their self-respect, feeling of femininity, sexuality and motherhood. That is why studies in this field serve as a paradigm for researches in psycho-oncology, since all the three modes of treatment are represented: surgical, radiotherapeutical and chemotherapeutical (Slevin, 1992; Fallow-field, 1993; Stcfanek, 1993; Noguchi et al., 1993; Jašović-Gašić et al, 1994). In our country such research was carried out only sporadically, unsystematically, so there is need for a good methodological procedure of analysis of these problems and we should try maximally to improve the quality of life of operated women. The aim of research is as follows: (1) To determine the quality of life of women, who due to breast cancer had surgical intervention: mastectomy or quadrantectomy. Under quality of life, so called psychosocial adaptation will be researched which includes: — emotional distress (anxiety and depressiveness) — disorders in the level of everyday living activities in family, social and professional spheres. (2) To analyze if there are differences between psychosocial adaptation of women who had various surgical interventions: mastectomy and quadrantectomy. (3) To determine possibility of social and psychotherapeutical intervention.