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Exploring the processes of DNA repair and homologous integration in Neurospora

Authors
Journal
Mutation Research/Reviews in Mutation Research
1383-5742
Publisher
Elsevier
Identifiers
DOI: 10.1016/j.mrrev.2011.06.003
Keywords
  • Neurospora Crassa
  • Dna Repair
  • Recombination
  • Homologous Integration
  • Mutagen Sensitivity
  • History Of Science
Disciplines
  • Medicine

Abstract

Abstract This review offers a personal perspective on historical developments related to our current understanding of DNA repair, recombination, and homologous integration in Neurospora crassa. Previous reviews have summarized and analyzed the characteristics of Neurospora DNA repair mutants. The early history is reviewed again here as a prelude to a discussion of the molecular cloning, annotation, gene disruption and reverse genetics of Neurospora DNA repair genes. The classical studies and molecular analysis are then linked in a perspective on new directions in research on mutagen-sensitive mutants.

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