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Impact of exercise training on redox signaling in cardiovascular diseases

Authors
Journal
Food and Chemical Toxicology
0278-6915
Publisher
Elsevier
Volume
62
Identifiers
DOI: 10.1016/j.fct.2013.08.035
Keywords
  • Free Radicals
  • Cardiac Disease
  • Physical Activity
  • Bioenergetics
  • Oxidative Stress
  • Oxidative Metabolism
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Reactive oxygen and nitrogen species regulate a wide array of signaling pathways that governs cardiovascular physiology. However, oxidant stress resulting from disrupted redox signaling has an adverse impact on the pathogenesis and progression of cardiovascular diseases. In this review, we address how redox signaling and oxidant stress affect the pathophysiology of cardiovascular diseases such as ischemia–reperfusion injury, hypertension and heart failure. We also summarize the benefits of exercise training in tackling the hyperactivation of cellular oxidases and mitochondrial dysfunction seen in cardiovascular diseases.

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