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Competitive peptide antagonists of ANF-induced cyclic guanosine monophosphate production

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
164
Issue
1
Identifiers
DOI: 10.1016/0006-291x(89)91689-6

Abstract

Abstract Atrial natriuretic factor (isoleucine ANF 101–126), cleaved ANF (isoleucine ANF 101–105/106–126) and des (Gln 18, Ser 19, Gly 20, Leu 21, Gly 22) ANF 4–23-NH2 (C-ANF 4–23) stimulated cyclic guanosine monophosphate production (cGMP) by rat aortic vascular smooth muscle cells (VSMC) in culture. Cleaved ANF and ANF C4–23 also antagonised or diminished the response to ANF 101–126. Agonist and antagonist actions of both peptides were dose-related. In contrast, prepro ANF (104–123), an ANF precursor fragment, exhibited no agonist or antagonist effect on cGMP production.

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