Affordable Access

Publisher Website

Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins

Authors
Journal
Neuron
0896-6273
Publisher
Elsevier
Publication Date
Volume
23
Issue
3
Identifiers
DOI: 10.1016/s0896-6273(00)80810-7
Disciplines
  • Biology

Abstract

Abstract Shank is a recently described family of postsynaptic proteins that function as part of the NMDA receptor–associated PSD-95 complex (Naisbitt et al., 1999 [this issue of Neuron]). Here, we report that Shank proteins also bind to Homer. Homer proteins form multivalent complexes that bind proline-rich motifs in group 1 metabotropic glutamate receptors and inositol trisphosphate receptors, thereby coupling these receptors in a signaling complex. A single Homer-binding site is identified in Shank, and Shank and Homer coimmunoprecipitate from brain and colocalize at postsynaptic densities. Moreover, Shank clusters mGluR5 in heterologous cells in the presence of Homer and mediates the coclustering of Homer with PSD-95/GKAP. Thus, Shank may cross-link Homer and PSD-95 complexes in the PSD and play a role in the signaling mechanisms of both mGluRs and NMDA receptors.

There are no comments yet on this publication. Be the first to share your thoughts.