Affordable Access

Publisher Website

Hematological toxicity associated with tiazofurin-influence on erythropoiesis

Authors
Journal
Toxicology Letters
0378-4274
Publisher
Elsevier
Publication Date
Volume
114
Identifiers
DOI: 10.1016/s0378-4274(99)00269-6
Keywords
  • Tiazofurin
  • Hematological Toxicity
  • Erythropoiesis
  • Cellularity Of Bone Marrow And Spleen
Disciplines
  • Medicine

Abstract

Abstract In this study hematological toxicity was analyzed after the single and repeated applications of tiazofurin (TZF). Cellularity of bone marrow, spleen and peripheral blood was examined, spanning the period of fifty days after the initial application. Analysis of hematological parameters was performed by slightly modified conventional techniques. The fraction of erythroid series was monitored during the experiment. Presented data describe kinetics of damage and recovery of hemopoietic tissue. Our results indicate that the effect of tiazofurin on cellularity of bone marrow and spleen and on erythropoiesis is reversible and dose dependent within tested dose range and therapeutic regimes. Twenty days after the application normal function of hemopoietic tissues was restored. This approach and results can be useful in defining the timing for sequencing and combination therapy with tiazofurin.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Clinical toxicity associated with tiazofurin.

on Investigational New Drugs May 1990

Hematological toxicity associated with tissue extr...

on Journal of Food Science September 2008

Hematological changes associated with egg producti...

on The Journal of experimental bi... September 2008
More articles like this..