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Solvophobic forces and molecular surface area changes in drug-biomolecule associations as with actinomycin-deoxyguanosine in a wide range of methanol/water mixtures

Authors
Journal
Biophysical Chemistry
0301-4622
Publisher
Elsevier
Publication Date
Volume
21
Identifiers
DOI: 10.1016/0301-4622(85)80003-x
Keywords
  • Biocomplex Denaturation
  • Solvophobic Bonding
  • Solvent Mixture
Disciplines
  • Physics

Abstract

Abstract A method is given to predict the unitary free energies of complexation between drug-like and nucleoside-like biomolecules in a range of mixed solvent compositions. A stability maximum for the actinomycin (A)-deoxyguanosine (D) complex at 8% MeOH (v/v) in methanol/water mixtures is correctly predicted by the theory in agreement with existing experimental data. The molecular surface areas of A and D exposed to the solvent are found to diminish by 36.4 Å 2 upon association. The ‘microthermodynamic differential surface tension’ of the solvophobic theory obtained for nucleoside-like and organic molecules in contact with MeOH/H 2O can be used to predict the solvent effect free energies in other such molecular or biopolymeric associations in solution.

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