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Effect of interleukin-6 polymorphisms on human longevity

Authors
Publication Date
Keywords
  • A Systematic Review And Meta-Analysis
  • Several Studies Have Assessed Changes In Frequency Of -174 Interleukin (Il)-6 Single Nucleotide Poly
  • If Il-6 Tracks With Disability And Age-Related Diseases
  • Then There Should Be Reduction
  • In The Oldest Old
  • Of The Frequency Of Homozygous Gg Subjects
  • Who Produce Higher Il-6 Levels
  • However
  • Discordant Results Have Been Obtained
  • To Explore The Relationship Between This Polymorphism And Longevity
  • We Analyzed Individual Data On Long-Living Subjects And Controls From Eight Case-Control Studies Con
  • Using Meta-Analysis
  • There Was No Significant Difference In The Il-6 Genotype Between The Oldest Old And Controls (Odds R
  • 96
  • 95% C
  • I
  • : 0
  • 77-1
  • 20
  • P=0
  • 71)
  • But There Was Significant Between-Study Heterogeneity (I2=55
  • 5%)
  • In A Subgroup Analyses When Male Centenarians From The Three Italian Studies Were Included
  • The Frequency Of The Il-6 -174 Gg Genotype Was Significantly Lower Than The Other Genotypes (Or=0
  • 49
  • 95% C
  • I
  • : 0
  • 31-0
  • 80
  • P=0
  • 004)
  • With No Evidence Ofheterogeneity (I2=0%)
  • Our Data Supports A Negative Association Between The Gg Genotype Of Il-6 Snp And Longevity In Italia
  • With Males Who Carry The Genotype Being Two Times Less Likely To Reach Extreme Old Age Compared With
  • These Findings Were Not Replicated In Other European Groups Suggesting A Possible Interaction Betwee
  • Sex And Environment In Reaching Longevity

Abstract

Open Learning SHORT, PART-TIME COURSES Autumn/New Year 2013-14 School of Education Open Learning Office Queen’s University Belfast 20 College Green Belfast BT7 1LN Northern Ireland T (028) 9097 3323/3539 F (028) 9097 1084 www.qub.ac.uk/edu/ol This publication is also available in alternative formats on request, including large print, Braille, tape, audio CD and Daisy CD. For further information, please contact the University’s Marketing and Creative Services Unit on +44 (0)28 9097 2586. Complementary Therapies Computing Counselling Creative Writing Cultural Studies Environment First Aid History and Politics Languages Law Leisure Literature Media Studies and Drama Music Personal Development Personal Finance Philosophy and Religion Science Visual Arts From Spanish to Wine Tasting, Creative Writing to Travel, World Literature to Visual Arts, there is a course for everyone in the Queen’s University Open Learning Programme. These part-time courses are open to all adults regardless of qualifications or experience and are offered during the day, evenings and weekends. For our Autumn/New Year programme we offer flexible, affordable open learning courses in the following subject areas: CDS 98413 Open Learning at Queen’s Autumn 2013 - New Year 2014 SCHOOL OF Education Q ueen’s U niversity B elfast Scho o l o f E d ucatio n O p en Learning A utum n/N ew Year Prog ram m e 2013-14 w w w .q ub .ac.uk/ed u/o l Education for Transformation School of Education – Open Learning Autumn/New Year Programme 2013/’14 1 School of Education Open Learning Autumn/New Year Programme 2013/’14 The Bridget Sarah Hurson Memorial Bursary The bursary is established in the memory of Bridget Sarah Hurson, late mother of Dr Tess Maginess and Ms Edna Gibson. Two bursaries, valued at £200 each, will be awarded this academic year. One will be awarded to a student facing financia

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