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Synthesis and evaluation of α-, β-glucosidase inhibition of 1-N-carboxamide-1-azafagomines and 5-epi-1-azafagomines

Authors
Journal
Carbohydrate Research
0008-6215
Publisher
Elsevier
Identifiers
DOI: 10.1016/j.carres.2014.06.015
Keywords
  • 1-Azafagomines
  • Glucosidases Inhibition
  • Aza-Diels–Alder

Abstract

Abstract 1-N-Carboxamide 1-azafagomines and 5-epi-1-azafagomines were obtained from 1-azafagomine and 5-epi-1-azafagomine. The hydroxyl groups and the N-2 pyridazine position were protected prior to reaction with different isocyanates to form ureas. Protective groups were removed leading to the target compounds in 18–23% global yields. Final compounds were tested towards α- and β-glucosidases.

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