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Determination of impurities in nucleoside 3′-phosphoramidites by fast atom bombardment mass spectrometry

Authors
Journal
Analytical Biochemistry
0003-2697
Publisher
Elsevier
Publication Date
Volume
152
Issue
2
Identifiers
DOI: 10.1016/0003-2697(86)90411-2
Keywords
  • Mass Spectrometry
  • Nucleotides
  • Nucleic Acid Chemistry
  • Oligonucleotide Synthesis
  • Phosphoramidites
  • Organic Chemistry

Abstract

Abstract Negative-ion fast atom bombardment mass spectrometry is quite useful for the identification of products and by-products formed during the synthesis of nucleoside 3′-phosphoramidites. The data shown that detritylation and oxidation are side reactions which occur during the synthesis of monomeric units used in the construction of oligodeoxyribonucleotides by the phosphite triester method.

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