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An improved synthetic method and the first crystal structures for (dihalomethylene)bisphosphonate partial esters

Authors
Journal
Tetrahedron
0040-4020
Publisher
Elsevier
Publication Date
Volume
51
Issue
24
Identifiers
DOI: 10.1016/0040-4020(95)00314-x

Abstract

Abstract A new general and selective strategy for the synthesis of (dihalomethylene)bisphosphonic acid (XYMBP) partial alkyl esters (PE) with high selectivity and purity has been developed. Preparation is started from selected XYMBP tetraesters using tertiary or secondary amines as dealkylating reagents leading to trialkyl or P,P′-dialkyl XYMBP PEs, respectively. The solid state structures are given for three of the compounds: Cl 2C[P(O)(OPr i)(O −Na +)][P(O)(O −Na +) 2] and Cl 2C[P(O)(OPr i)(O −X +)] 2, where X=Na + or H 2N +(CH 2CH 2) 2O.

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