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Molecular Cloning of the Genes Encoding the PR55/Bβ/δ Regulatory Subunits for PP-2A and Analysis of Their Functions in Regulating Development of Goldfish, Carassius auratus

Libertas Academica
Publication Date
  • Gene Regulation And Systems Biology
  • Volume: 2010
  • Issue: 4
  • Biology
  • Chemistry
  • Education


Open Access Full open access to this and thousands of other papers at Gene Regulation and Systems Biology 2010:4 135–148 doi: 10.4137/GRSB.S6065 This article is available from © the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited. Gene Regulation and Systems Biology O R i G i n A L R e S e A R c h Gene Regulation and Systems Biology 2010:4 135 Molecular cloning of the Genes encoding the pR55/Bβ/δ Regulatory subunits for pp-2A and Analysis of Their Functions in Regulating Development of Goldfish, Carassius auratus Jun-Qiong Zhao1*, Si-Si Xie1*, Wen-Bin Liu1*, Ya-Mei Xiao1*, Xiao-Ming Zeng1, Mi Deng2, Lili Gong2, Jin-Ping Liu2, Pei-chao chen1, Jie Zhou1, Xiao-hui hu1, Jia-han Lv1, Xiang-Qian Yu1, Dao Wang1, chi Li1, Yun-Lei Peng1, Gao-Peng Liao1, Yun Liu1 and David Wan-cheng Li2,1,3** 1Key Laboratory of Protein chemistry and Developmental Biology of educational Ministry of china, college of Life Sciences, hunan normal University, changsha, hunan 410081, china. 2Departments of Biochemistry and Molecular Biology, 3Ophthalmology and Visual Sciences, University of nebraska Medical center, Omaha, nebraska 68198-5870, USA. *These authors have contributed equally. **corresponding author email: [email protected] com Abstract: The protein phosphatase-2A (PP-2A), one of the major phosphatases in eukaryotes, is a heterotrimer, consisting of a scaffold A subunit, a catalytic C subunit and a regulatory B subunit. Previous studies have shown that besides regulating specific PP-2A activity, various B subunits encoded by more than 16 different genes, may have other functions. To explore the possible roles of the regulatory subunits of PP-2A in vertebrate development, we have cloned the PR55/B family regulatory subunits: β and δ, analyzed their tissue specific and developmental expression patt

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