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Role of active oxygen species and antioxidants in photoaging

Authors
Journal
Journal of Dermatological Science
0923-1811
Publisher
Elsevier
Publication Date
Volume
27
Identifiers
DOI: 10.1016/s0923-1811(01)00120-7
Keywords
  • Singlet Oxygen
  • Superoxide
  • Hydrogen Peroxide
  • Hydroxyl Radical
  • Atocopherol
  • Ubiquinol
  • Ascorbic Acid
  • Glutathione
  • Lipid Hydroperoxide
  • Squalene Hydroperoxide

Abstract

Abstract The mechanism for the formation of active oxygen species and their reactions with antioxidants is described. The importance of the free radical chain oxidation and the singlet oxygen-dependent oxidation is suggested by a decrease in skin levels of α-tocopherol, ubiquinol-10, and ascorbic acid with a concomitant formation of lipid hydroperoxides during UV irradiation of murine skin, and the formation of squalene hydroperoxides in human skin upon UV exposure, respectively.

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