Affordable Access

Publisher Website

Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by a Retrovirus

Authors
Journal
Journal of Virology
0022-538X
Publisher
American Society for Microbiology
Publication Date
Volume
78
Issue
2
Identifiers
DOI: 10.1128/jvi.78.2.576-584.2004
Keywords
  • Pathogenesis And Immunity

Abstract

Mouse mammary tumor virus (MMTV) is a milk-borne retrovirus that exploits the adaptive immune system. It has recently been shown that MMTV activates B cells via Toll-like receptor 4 (TLR4), a molecule involved in innate immune responses. Here, we show that direct virus binding to TLR4 induced maturation of bone marrow-derived dendritic cells and up-regulated expression of the MMTV entry receptor (CD71) on these cells. In vivo, MMTV increased the number of dendritic cells in neonatal Peyer's patches and their expression of CD71; both these effects were dependent on TLR4. Thus, retroviral signaling through TLRs plays a critical role in dendritic-cell participation during infection.

There are no comments yet on this publication. Be the first to share your thoughts.