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Mutagen and anti-mutagen in ginger,Zingiber officinale

Authors
Journal
Mutation Research Letters
0165-7992
Publisher
Elsevier
Publication Date
Volume
103
Issue
2
Identifiers
DOI: 10.1016/0165-7992(82)90016-1
Disciplines
  • Chemistry

Abstract

Abstract When rhizome juice of ginger, Zingiber officinale, was added to a solution of 2(2-furyl)-3-(5-nitro-2-furyl)acryl amide (AF2) or N-methyl- N′-nitro- N-nitro-soguanidine (NTG), mutagenesis by these chemicals was markedly increased. As a result of the component fractionation of the ginger juice, it was found that [6]-gingerol was a potent mutagen. However, the ginger juice also contained anti-mutagenic component(s) against [6]-gingerol (CAS No. 58253-27-3) (present study) and tryptophan pyrolysates (Kada et al., 1978; Morita et al., 1978). It is suggested, therefore, that the [6]-gingerol component may be mutagenically activated by the presence of AF2 and NTG.

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