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Inhibition of human leukocyte elastase. 6. Inhibition by 6-substituted penicillin esters.

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
3
Issue
11
Identifiers
DOI: 10.1016/s0960-894x(01)80940-9

Abstract

Abstract Penicillin esters substituted at C-6 with a variety of functionalities are reported as human leukocyte elastase (HLE) inhibitors. The structure activity relations for the esters and C-6 derivatives are discussed and compared to the known cephalosporin structures.

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