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Monoclonal Antibodies in Therapy of Solid Tumors

Authors
Journal
Surgical Oncology Clinics of North America
1055-3207
Publisher
Elsevier
Publication Date
Volume
16
Issue
4
Identifiers
DOI: 10.1016/j.soc.2007.07.001
Disciplines
  • Medicine

Abstract

Monoclonal antibodies have become increasingly used therapeutic agents for the treatment of solid cancer. Many are now being tested as components of adjuvant or first-line therapies to assess their efficacy in improving or prolonging survival. Selected unconjugated antibodies can exert clinically significant antitumor effects in many cancers. Antibody conjugates have been used to deliver toxic principles, such as radioactive particles, chemotherapeutic agents, and catalytic toxins, with increasing success in clinical trails.

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