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A novel enzyme mimic for thiazolium-catalyzed α-ketoacid decarboxylation

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
29
Issue
48
Identifiers
DOI: 10.1016/s0040-4039(00)82313-8
Disciplines
  • Biology

Abstract

Abstract The covalent combination of the thiazolium heterocycle of thiamine with macrotricyclic quaternary ammonium receptor units yields the enzyme mimics 3a,b , which show enhanced substrate selectivity and catalytic activity in decarboxylations of α-ketoacids compared to simpler salts lacking the receptor substructure.

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