Affordable Access

Publisher Website

Lysosome recruitment during host cell invasion byTrypanosoma cruzi

Authors
Journal
Trends in Cell Biology
0962-8924
Publisher
Elsevier
Publication Date
Volume
5
Issue
3
Identifiers
DOI: 10.1016/s0962-8924(00)88965-5
Keywords
  • Microbial Subversion Of Phagocytosis

Abstract

Abstract The protozoan parasite Trypanosoma cruzi uses an unusual mechanism to enter cells. Recent observations revealed that instead of trypanosomes being brought in to fuse with lysosomes, it is the lysosomes that migrate to the trypanosomes and actually participate in their internalization. Signalling events involving intracellular free Ca 2+ occur upon contact of the parasites with host cells and may contribute to the regulation o f this unusual process.

There are no comments yet on this publication. Be the first to share your thoughts.