Affordable Access

Signal-transduction networks and the regulation of muscle protein degradation

Authors
Journal
The International Journal of Biochemistry & Cell Biology
1357-2725
Publisher
Elsevier
Publication Date
Volume
37
Issue
10
Identifiers
DOI: 10.1016/j.biocel.2005.02.020
Keywords
  • Proteolysis
  • Atrophy
  • Turnover
  • Wasting
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Protein degradation in muscle functions in maintaining normal physiological homeostasis and adapting to new homeostatic states, and is required for muscle wasting or atrophy in various pathological states. The interplay between protein synthesis and degradation to maintain homeostasis is complex and responds to a variety of autocrine and intercellular signals from neuronal inputs, hormones, cytokines, growth factors and other regulatory molecules. The intracellular events that connect extracellular signals to the molecular control of protein degradation are incompletely understood, but likely involve interacting signal-transduction networks rather than isolated pathways. We review some examples of signal-transduction systems that regulate protein degradation, including effectors of proteolysis inducing factor (PIF), insulin and insulin-like growth factor (IGF) and their receptors, and fibroblast growth factor (FGF) and its receptors.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Signal-transduction networks and the regulation of...

on The International Journal of B... October 2005

[RGS and the regulation of G protein signal transd...

on Sheng li ke xue jin zhan [Prog... October 2000

Roles of protein kinase C and α-tocopherol in regu...

on Free Radical Biology and Medic... Jan 01, 2002
More articles like this..