Affordable Access

Publisher Website

Study design for the identification of loci affecting human longevity

Authors
Journal
Fibrinolysis and Proteolysis
0268-9499
Publisher
Elsevier
Publication Date
Volume
10
Identifiers
DOI: 10.1016/s0268-9499(96)80038-5
Disciplines
  • Biology
  • Design
  • Medicine

Abstract

Summary The genetic component of human longevity is estimated at 30%. Which genes are involved in determining human longevity, however, is largely unknown. Genes that may affect human survival are susceptibility loci for major age-related pathologies. Many studies are being performed to identify such loci for cardiovascular disease, dementia and diabetes. In order to establish how these loci relate to survival, we have initiated a genetic association study in populations of the oldest old. On the basis of the study design optimised approaches to identify loci affecting human longevity are discussed.

There are no comments yet on this publication. Be the first to share your thoughts.