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Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans

Authors
Journal
Prostaglandins & Other Lipid Mediators
1098-8823
Publisher
Elsevier
Volume
107
Identifiers
DOI: 10.1016/j.prostaglandins.2013.04.003
Keywords
  • Pufas
  • Metabolites
  • Isoprostanes
  • Neuroprostanes
  • Biomarkers
  • Bioactive Lipids
Disciplines
  • Biology

Abstract

Abstract Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.

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