Affordable Access

Publisher Website

Chronic human parvovirus B19 infection in rheumatic disease of childhood and adolescence

Authors
Publisher
Elsevier B.V.
Publication Date
Volume
25
Issue
2
Identifiers
DOI: 10.1016/s1386-6532(01)00247-5
Keywords
  • Parvovirus B19
  • Ns1-Protein
  • Juvenile Arthritis
  • Viral Persistence
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Parvovirus B19 causes erythema infectiosum in children, but the virus is associated with an increasing range of different diseases. About 20% of infections are associated with delayed virus elimination and viremia persisting over several months or years. These persistent B19-infections are characterised by the presence of IgG against the non-structural protein NS1. This study aimed to find further evidence for an association of parvovirus B19 persistence with VP1/2- and NS1-specific IgG-antibodies in children suffering from rheumatic diseases of childhood. Forty-eight children and adolescents with joint complaints lasting longer than 1 year including patients with juvenile systemic sclerosis and juvenile dermatomyositis showed antibodies against the viral NS1-protein. Laboratory markers of inflammation, humoral immune response against parvovirus B19 proteins and the presence of viral genomes in patients’ sera as well as in 124 healthy children were investigated. Almost 50% of the patients showed laboratory signs of chronic inflammation. B19-DNA was amplified in 31% of patients’ sera and 7% of the controls ( P<0.0001). VP2-specific IgM was detectable in 50% of the patients’ and 6% of control sera. NS1-specific immune reactions were linked to persistent B19-infection as indicated by the presence of viral genomes in the peripheral blood and of VP2-specific IgM years after disease onset. To estimate the severity of the disease and the clinical course, the number of affected and functionally impaired joints were noted and compared with the records from patients’ initial visit in the hospital. Disease related complications were registered. Impairment of activities of daily living was assessed by Childhood Health Assessment Questionnaire (CHAQ)- and Munich Quality of Life Questionnaire (KINDL)-tests. During observation the clinical state of four patients worsened, 27 improved, the others remained stable. Twenty-four children were restricted in their daily activities.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Chronic human parvovirus B19 infection in rheumati...

on Journal of Clinical Virology August 2002

Parvovirus B19 infection and rheumatic diseases.

on Revue du rhumatisme (English e... December 1996

Chronic human parvovirus B19 infection associated...

on The Israel Medical Association... October 2002

Pathogenesis of human parvovirus B19 in rheumatic...

on Annals of the Rheumatic Diseas... September 2000
More articles like this..