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Enantioselective trimethylsilylcyanation of aldehydes

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
36
Issue
10
Identifiers
DOI: 10.1016/0040-4039(95)00123-t
Keywords
  • Asymmetric Trimethylsilylcyanation
  • Sulfoximines
  • Enantioselective Formation Of Cyanohydrins
  • Chiral Titanium Reagents

Abstract

Abstract A chiral titanium reagent derived from optically active sulfoximine (R)- 3 and Ti(O- i-Pr) 4 promotes the asymmetric addition of trimethylsilylcyanide to aldehydes affording cyanohydrins in high yields with good enantioselectivities (up to 91% ee).

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