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Statistical mechanics of protein-like heteropolymers

Authors
Publisher
The National Academy of Sciences
Publication Date
Source
PMC
Keywords
  • Biological Sciences
Disciplines
  • Design

Abstract

A strategy is outlined for obtaining the free energy of a typical designed heteropolymer. The design procedure considers the probability that the target conformation is occupied in comparison with all the other conformations that could house the given sequence. Numerical calculations on lattice heteropolymer models are presented to illustrate the key physical principles.

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