Affordable Access

Publisher Website

Accurate and robust brain image alignment using boundary-based registration

Publication Date
DOI: 10.1016/j.neuroimage.2009.06.060
  • Computer Science


Abstract The fine spatial scales of the structures in the human brain represent an enormous challenge to the successful integration of information from different images for both within- and between-subject analysis. While many algorithms to register image pairs from the same subject exist, visual inspection shows that their accuracy and robustness to be suspect, particularly when there are strong intensity gradients and/or only part of the brain is imaged. This paper introduces a new algorithm called Boundary-Based Registration, or BBR. The novelty of BBR is that it treats the two images very differently. The reference image must be of sufficient resolution and quality to extract surfaces that separate tissue types. The input image is then aligned to the reference by maximizing the intensity gradient across tissue boundaries. Several lower quality images can be aligned through their alignment with the reference. Visual inspection and fMRI results show that BBR is more accurate than correlation ratio or normalized mutual information and is considerably more robust to even strong intensity inhomogeneities. BBR also excels at aligning partial-brain images to whole-brain images, a domain in which existing registration algorithms frequently fail. Even in the limit of registering a single slice, we show the BBR results to be robust and accurate.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Fast and accurate registration techniques for affi...

on Annals of Biomedical Engineeri... January 2010

Robust feature-based registration using a Gaussian...

on Computers in Biology and Medic... Jan 01, 2008

Deformable registration of histological sections t...

on Annual International Conferenc... 2011

Intensity-based image registration using robust co...

on IEEE Transactions on Medical I... November 2004
More articles like this..