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Charge transport in cancer-related genes and early carcinogenesis

Elsevier Science BV
Publication Date
  • Qc Physics
  • Qh426 Genetics
  • Rc0254 Neoplasms. Tumors. Oncology (Including Cancer)
  • Biology
  • Medicine


The electronic transmission properties of DNA molecules are believed to play a significant role in many physical phenomena taking place in living organisms (Chakraborty 2007) [1] Here we study the charge transport (CT) properties of cancer-related genes including some of the most important tumor suppressors We find that the changes in averaged CT around the sites of pathogenic and cancerous mutations are statistically smaller than those on sites where pathogenic mutations have not been observed The results suggest that CT might be an indicator to discriminate between pathogenic and non-pathogenic mutations at an early stage Mutations which cause little change in CT may be more likely to occur or more likely to be missed by damage-repair enzymes which probe CT and are therefore more likely to persist and cause disease Crown Copyright (C) 2010 Published by Elsevier BV All rights reserved

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