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Multiple control level governing H1omRNA and protein accumulation

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
283
Issue
1
Identifiers
DOI: 10.1016/0014-5793(91)80554-g
Keywords
  • H3
  • Dna Replication
  • Hepatectomy
  • Translational Control
Disciplines
  • Biology

Abstract

Abstract We have studied the variation of histone H1 o and its coding mRNA during rat liver regeneration after partial hepatectomy. Our data showed that while H1 o decreased when cell proliferation was initiated, H1 o mRNA accumulated in a proliferantion-dependent manner as did H3 mRNA. These results showed two interesting aspects of the regulation of H1 o expression in vivo, confirming results we have obtained previously in vitro: first H1 o mRNA accumulation is a proliferation-dependent event; second, H1 o protein accumulation may be uncoupled from that of its coding mRNA.

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