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Pharmacokinetics of the venom ofBothrops erythromelaslabeled with131I in mice

Authors
Journal
Toxicon
0041-0101
Publisher
Elsevier
Publication Date
Volume
52
Issue
3
Identifiers
DOI: 10.1016/j.toxicon.2008.06.016
Keywords
  • Pharmacokinetics
  • Bothrops Erythromelas
  • Plasma Distribution
Disciplines
  • Pharmacology

Abstract

Abstract Bothrops erythromelas venom (BeV) has been responsible for many snake accidents in Brazil. We investigated the plasmatic pharmacokinetic of BeV labeled with 131I in the absence and the presence of anti- Bothrops serum (BAS). A higher percentage of BeV plasmatic radioactivity and longer elimination were found in the presence of BAS. Our results showed a redistribution of venom from the tissue to vascular compartment associated with the treatment of envenomed mice with anti-venom 15 min after venom injection.

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