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Fructose 2,6-bisphosphate levels are elevated in livers of genetically obese mice

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
109
Issue
3
Identifiers
DOI: 10.1016/0006-291x(82)91991-x

Abstract

Abstract Fructose 2,6-bisphosphate levels in freeze-clamped livers of C57BL 6J ob ob mice were 6-fold higher than the level in their lean (+/?) littermates. Overnight starvation reduced the hepatic level of this unique sugar diphosphate to 0.2 nmol/g in both the obese and lean mice. The elevated level in the obese mouse is consistent with the hyperinsulinemia of these animals.

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