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Induction of apoptosis in murine ACTH-secreting pituitary adenoma cells by bromocriptine

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
339
Identifiers
DOI: 10.1016/0014-5793(94)80387-0
Keywords
  • Apoptosis
  • Pituitary Tumor
  • Bromocriptine
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Bromocriptine, a dopamine agonist, is now an accepted primary therapeutic agent for patients with prolactinomas and other pituitary adenomas. In this study, we demonstrated that bromocriptine inhibited the proliferation of murine ACTH-secreting pituitary adenoma (AtT-20) cells. In addition, the antitumor activity of bromocriptine was inhibited both by actinomycin D and cycloheximide, suggesting that it was dependent on new RNA and protein synthesis. Interestingly, the results of DNA fragmentation assays and cell cycle analysis clearly demonstrated that bromocriptine induced apoptosis in AtT-20 cells.

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