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An enantioselective total synthesis of (+)-cassiol

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
37
Issue
51
Identifiers
DOI: 10.1016/s0040-4039(96)02191-0

Abstract

Abstract An enantioselective total synthesis of (+)-cassiol 1 possessing potent antiulcerogenic activity has been accomplished by using an efficient construction methodology of the asymmetric quaternary carbon center via a highly diastereoselective intramolecular [3+2] dipolar cycloaddition reaction of the nitrile oxide 10 as a key step.

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