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Changes in lung activity of superoxide dismutase and copper concentration during lung tumorigenesis by hydralazine in Swiss mice

Authors
Journal
Experimental Pathology
0232-1513
Publisher
Elsevier
Publication Date
Volume
32
Issue
2
Identifiers
DOI: 10.1016/s0232-1513(87)80068-3
Keywords
  • Lung Cancer
  • Hydralazine-Side Effects
  • Copper
  • Superoxide Dismutase
  • Chemical Tumorigenesis
  • Free Radicals
  • Superoxide Radical Ion
  • Carcinogenesis
Disciplines
  • Medicine

Abstract

Summary Hydralazine (1-hydrazinophthalazine) was administered in drinking water as a 0.0312% solution to randomly bred Swiss mice for life beginning at 5 weeks of age. The treatments gave rise to statistically significant incidences of lung tumors: 55% in females and 43% in males. A decreased copper concentration and superoxide dismutase activity in the lung of mice were observed. The role of copper and superoxide dismutase in the malignant process is briefly discussed.

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