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C-linked pyrazole biaryl tetrazoles as antagonists of angiotensin II

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
2
Issue
10
Identifiers
DOI: 10.1016/s0960-894x(00)80222-x

Abstract

Abstract The identification of a novel series of C-linked pyrazole biaryl tetrazole antagonists of angiotensin II is described. These compounds are highly potent in vitro (pK B ca . 10) and some examples cause significant reductions in blood pressure at 1mgkg −1 p.o in renal hypertensive rats.

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