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Mitochondrial Disease: mtDNA and Protein Segregation Mysteries in iPSCs

Authors
Journal
Current Biology
0960-9822
Publisher
Elsevier
Publication Date
Volume
23
Issue
23
Identifiers
DOI: 10.1016/j.cub.2013.10.048
Disciplines
  • Computer Science
  • Medicine

Abstract

Summary Mitochondrial diseases cause a range of clinical manifestations even in patients carrying the same mtDNA mutations. New work reveals that a common disease-associated mtDNA mutation is selectively segregated from wild-type mtDNA during the reprogramming of induced pluripotent stem cells and that high levels of this mutation in differentiated neurons upregulate Parkin-mediated mitophagy.

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