Publisher Summary ZigBee networking has a diverse range of application scenarios in which ZigBee devices can increase efficiency or reduce cost. Full ZigBee protocol implementation has the advantage of reliable mesh networking capability. However, if the application is simple, it might be possible to implement only IEEE 802.15.4 layers. Home automation is one of the major application areas for ZigBee wireless networking. Home automation uses include security systems, meter reading systems, irrigation systems, light control systems, and multizone heating, ventilation, and air-conditioning (HVAC) systems. In consumer electronics, ZigBee can be used in wireless remote controls, game controllers, a wireless mouse for a personal computer, and many other applications. This chapter reviews the application of ZigBee in wireless remotes. At the industrial level, ZigBee mesh networking can help in areas such as energy management, light control, process control, and asset management. This application includes asset management and personnel tracking and livestock tracking. Furthermore, ZigBee also finds its application in the sector of healthcare. A ZigBee gateway provides the interface between a ZigBee network and other networks, such as an Internet Protocol (IP) network, thus helping hospitals improve patient care and relieve hospital overcrowding by enabling them to monitor patients at home. Some other applications of ZigBee devices include hotel room guest access and fire extinguishers.