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Novel oligodeoxyribonucleotides incorporating L-related isodeoxynucleosides: Solid phase synthesis, enzymology, and CD studies

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
7
Issue
24
Identifiers
DOI: 10.1016/s0960-894x(97)10183-4
Disciplines
  • Physics

Abstract

Abstract The synthesis of self-complementary oligodeoxyribonucleotides incorporating the L-related isodeoxynucleosides, isodA, ( 1) and/or isodT ( 4) is described. These novel oligomers exhibit high resistance towards exonucleases. Temperature- and concentration-dependent CD spectra and thermodynamic data of the oligomers show that isodA-isodT base pairs participate in duplex stabilization.

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