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An efficient preparation ofN-alkyl-2-benzazepine derivatives and investigation of their biological activity

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
19
Issue
12
Identifiers
DOI: 10.1016/j.bmcl.2009.04.117
Keywords
  • 2-Benzazepines
  • Sar Studies
  • Hacat Cell
  • Epithelial Cell Migration
  • Promotion Of Skin Wound
  • Radical Cyclization
  • N-Alkylation

Abstract

Abstract N-Alkyl-2-benzazepine derivatives are readily prepared through N-alkylation of secondary 2-benzazepines that are constructed via 7-endo selective cyclization of radical cyclization of N-boc- N-(2-bromo-5-methoxyphenylmethyl) methacrylamides. The structure and activity relationship of these derivatives are examined.

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