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Experimental Mucosal Infection with Molecularly Cloned Feline Immunodeficiency Viruses

Authors
Publisher
American Society for Microbiology
Publication Date
Source
PMC
Keywords
  • Microbial Immunology

Abstract

Four of six specific pathogen-free cats were infected after intravaginal exposure to molecularly cloned lymphotropic but non-Crandell feline kidney (CRFK)-tropic feline immunodeficiency virus strain TM2 and its AP-1 deletion mutant. The sequences of the env V3-to-V5 region which defines the CRFK tropism were unchanged in the infected cats through the infection. These data suggest that the strain was transmitted across the mucosal epithelium without a broadening of cell tropism.

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