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Abscisic Acid Suppresses the Highly Occurred Somatic Homologous Recombination inArabidopsis rfc1Mutant

Authors
Journal
Journal of Genetics and Genomics
1673-8527
Publisher
Elsevier
Publication Date
Volume
40
Issue
9
Identifiers
DOI: 10.1016/j.jgg.2013.05.006
Keywords
  • Abscisic Acid
  • Dna Replication Factor C1
  • Genomic Stability

Abstract

Abstract The phytohormone abscisic acid (ABA) regulates many aspects of plant growth, including seed germination, root growth and cell division. Previous study indicates that ABA treatment increases DNA damage and somatic homologous recombination (HR) in Arabidopsis abo4/pol ɛ (aba overly-sensitive 4 /DNA polymerase ɛ) mutants. DNA replication factor C (RFC) complex is required for loading PCNA (Proliferating Cell Nuclear Antigen) during DNA replication. The defect in RFC1, the largest subunit of RFC, causes the high HR and DNA damage sensitivity in Arabidopsis. Here we found that like pol ε/abo4, rfc1 is sensitive to ABA in both ABA-inhibiting seed germination and root growth. However, ABA treatment greatly reduces HR and also reduces the expression of the DNA-damaged marker genes in rfc1. These results suggest that RFC1 plays critical roles in ABA-mediated HR in Arabidopsis.

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