Affordable Access

Publisher Website

AMPA-selective glutamate receptor subunits and their relation to glutamate-and GABA-like immunoreactive terminals in the nucleus submedius of the rat

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
217
Identifiers
DOI: 10.1016/0304-3940(96)13093-7
Keywords
  • Receptor
  • Glutamate
  • Non-N-Methyl-D-Aspartate
  • Pain
  • Thalamus
  • Electron Microscopy
  • Postembedding Immunohistochemistry
Disciplines
  • Chemistry

Abstract

Abstract Glutamate plays an important role in supraspinal nociceptive systems. Thus, glutamate is present in the nucleus submedius of the medial thalamus, a major relay for nociceptive information. In this study, immunoreactivity for the four subunits (GluR1–4) of α-amino-3-hydroxy-5-methyl-4-isoxasoleproprionate (AMPA) receptors was examined by a preembedding immunohistochemical method in order to evaluate the presence of this glutamate receptor subtype in the nucleus submedius. Combining the preembedding method with a postembedding immunogold technique, we found that AMPA receptor-like immunoreactivity was present postsynaptically to glutamatergic terminals but not to terminals containing γ-arninobutyric acid (GABA). These findings suggest a role for AMPA receptors in excitatory synaptic transmission in the nucleus submedius of the rat thalamus.

There are no comments yet on this publication. Be the first to share your thoughts.