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The effects of lycopene intake and exercise on bone health in young female rats

Journal of the International Society of Sports Nutrition
Springer (Biomed Central Ltd.)
Publication Date
DOI: 10.1186/1550-2783-8-s1-p30
  • Poster Presentation
  • Biology


The effects of lycopene intake and exercise on bone health in young female rats POSTER PRESENTATION Open Access The effects of lycopene intake and exercise on bone health in young female rats Yuya Kakutani1*, Yuki Aikawa1, Ikuko Ezawa2, Naomi Omi1 From International Society of Sports Nutrition: 8th Annual ISSN Conference and Expo Las Vegas, NV, USA. 24-25 June 2011 Background Oxidative stress caused by free radicals and antioxidant imbalance damage cellular lipids, proteins and DNA. Recently, some studies have demonstrated that oxidative stress is a key modulator of bone cell function and that oxidative status influences the pathophysiology of bone. Endurance exercise is effective for antioxidant enzyme activity enhancement and the bone formation enhance- ment. On the other hand, lycopene is a kind of carote- noids had a higher antioxidant capability to reduce oxidative stress caused by exercise. In addition, several studies have reported that lycopene is effective for sup- pressing bone resorption. Thus, we considered that combining exercise and lycopene can contribute to bone health. The aim of this study was to investigate the effects of combining exercise and lycopene intake on bone health. Methods Female Wistar rats, 6 weeks old, were fed for 10 weeks. Rats were divided into four groups for; sedentary control (C), sedentary control with lycopene intake (Ly), training exercise (T), and training with lycopene intake (TLy). Incidentally, concentration of lycopene in the diet was adjusted to 100ppm using a tomato oleoresin containing 6% lycopene. Rats in the two training groups were trained at 6 times a week for 9 weeks by treadmill run- ning. All rats were given diets and distilled water ad libitum. Breaking force and breaking energy of femoral diaphysis and bone mineral content (BMC) and bone mineral density (BMD) of tibia were measured after dis- section and were corrected body weight except for BMD. Data were analyzed using un-paired t test and two-way ANOVA with an alpha

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