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C-kit-positive cells accumulate in remodeled vessels of idiopathic pulmonary arterial hypertension.

Authors
  • Montani, David
  • Perros, Frédéric
  • Gambaryan, Natalia
  • Girerd, Barbara
  • Dorfmuller, Peter
  • Price, Laura C
  • Huertas, Alice
  • Hammad, Hamida
  • Lambrecht, Bart
  • Simonneau, Gérald
  • Launay, Jean-Marie
  • Cohen-Kaminsky, Sylvia
  • Humbert, Marc
Type
Published Article
Journal
American Journal of Respiratory and Critical Care Medicine
Publisher
American Thoracic Society
Publication Date
Jul 01, 2011
Volume
184
Issue
1
Pages
116–123
Identifiers
DOI: 10.1164/rccm.201006-0905OC
PMID: 21471108
Source
Medline
License
Unknown

Abstract

In IPAH, c-kit(+) cells infiltrate pulmonary arterial lesions and may participate to vascular remodeling. Therefore, c-kit may represent a potential target for innovative PAH therapy.

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