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A C-14 labeled Py-Im polyamide localizes to a subcutaneous prostate cancer tumor.

Authors
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry
Publisher
Elsevier
Volume
22
Issue
16
Pages
4371–4375
Identifiers
DOI: 10.1016/j.bmc.2014.04.010
Source
UCSC Cancer biomedical-ucsc
License
Unknown

Abstract

In an effort to quantitate Py-Im polyamide concentrations in vivo, we synthesized the C-14 radioactively labeled compounds 1-3, and investigated their tumor localization in a subcutaneous xenograft model of prostate cancer (LNCaP). Tumor concentrations were compared with representative host tissues, and exhibited a certain degree of preferential localization to the xenograft. Compound accumulation upon repeated administration was measured. Py-Im polyamide 1 was found to accumulate in LNCaP tumors at concentrations similar to the IC50 value for this compound in cell culture experiments.

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