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Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing

Authors
  • Karunakaran, Mohindar M.1
  • Willcox, Carrie R.2, 3
  • Salim, Mahboob2, 3
  • Paletta, Daniel1
  • Fichtner, Alina S.1
  • Noll, Angela4
  • Starick, Lisa1
  • Nöhren, Anna1
  • Begley, Charlotte R.2, 3
  • Berwick, Katie A.2, 3
  • Chaleil, Raphaël A.G.5
  • Pitard, Vincent6, 7
  • Déchanet-Merville, Julie6, 7
  • Bates, Paul A.5
  • Kimmel, Brigitte8
  • Knowles, Timothy J.9
  • Kunzmann, Volker8
  • Walter, Lutz4
  • Jeeves, Mark10
  • Mohammed, Fiyaz2, 3
  • And 2 more
  • 1 Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany
  • 2 Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK
  • 3 Cancer Immunology and Immunotherapy Centre, University of Birmingham, Birmingham, UK
  • 4 Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Göttingen, Germany
  • 5 Biomolecular Modelling Laboratory, The Francis Crick Institute, London, UK
  • 6 ImmunoConcEpT Laboratory, Equipe labellisée, LIGUE 2017, UMR 5164, Bordeaux University, CNRS, 33076 Bordeaux, France
  • 7 Flow Cytometry Facility, TransBioMed Core, Bordeaux University, CNRS UMS 3427, INSERM US05, 33076 Bordeaux, France
  • 8 Medical Clinic and Policlinic II, University of Würzburg, Würzburg, Germany
  • 9 School of Biosciences, University of Birmingham, Birmingham, UK
  • 10 Henry Wellcome Building for NMR, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK
Type
Published Article
Journal
Immunity
Publication Date
Mar 17, 2020
Volume
52
Issue
3
Pages
487–498
Identifiers
DOI: 10.1016/j.immuni.2020.02.014
PMID: 32155411
PMCID: PMC7083227
Source
PubMed Central
Keywords
License
Unknown

Abstract

Karunakaran et al. find that butyrophilin 2A1 (BTN2A1) associates with BTN3A1 on the cell surface and binds directly to germline-encoded regions of the Vγ9 chain of the Vγ9Vδ2 TCR. Thus, BTN2A1 collaborates with BTN3A1 to potentiate Vγ9Vδ2 T cell recognition, playing an essential role in phosphoantigen sensing.

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