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Budding yeast mitotic chromosomes have an intrinsic bias to biorient on the spindle.

Authors
  • Indjeian, Vahan B
  • Murray, Andrew W
Type
Published Article
Journal
Current Biology
Publisher
Elsevier
Publication Date
Nov 06, 2007
Volume
17
Issue
21
Pages
1837–1846
Identifiers
PMID: 17980598
Source
Medline
License
Unknown

Abstract

These observations argue that budding yeast mitotic chromosomes have an intrinsic, geometric bias to biorient on the spindle. When the poles have already separated, attaching one kinetochore to one pole predisposes its sister to attach to the opposite pole, allowing the cells to segregate the chromosomes correctly. When the poles have not separated, the second kinetochore eventually attaches to either of the two poles randomly, causing orientation errors that are corrected in the wild-type but not in sgo1 mutants. In the absence of spindle damage, sgo1 cells divide successfully, suggesting that kinetochores only make stable attachments to microtubules after the cells have entered mitosis and separated their spindle poles.

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